Which Harmony remote do you have?
Harmony just provided us with their protocol for the hub to talk directly to myServer.
We haven't started any development yet, but we do believe this will be a popular solution so we will be supporting it.
I think you will find that you will use a phone / tablet for everything but volume up / down and channel up / down.
Have you gotten Weather, Internet Radio, Pandora, TuneIn, RSS feeds, myMusic, Horoscope, Calendar, etc all working?